|
KMID : 1161420190220090875
|
|
Journal of Medicinal Food
2019 Volume.22 No. 9 p.875 ~ p.884
|
|
|
A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis
|
|
Hewlings Susan
Kalman Douglas
Schneider Luke V.
|
|
|
Abstract
|
|
|
|
Osteoarthritis (OA) is a chronic condition that impacts quality of life and functionality for which consumers often seek dietary supplements to provide some relief. The purpose of this double-blind, placebo-controlled clinical trial was to assess the safety and efficacy of a water-soluble chicken eggshell membrane hydrosylate (WSEM) dietary supplement (BiovaFlex®) 450?mg daily on knee function, mobility, and general health and well-being in 88 adults with OA randomized into intervention (n?=?44) or placebo (n?=?44) groups. Outcomes were assessed periodically over 12 weeks, including the Western Ontario McMaster Osteoarthritis Index (WOMAC), the six-minute walk test (6MWT), knee range of motion (ROM) testing, and safety. Normalized analysis (improvement over baseline) showed that the poorest initial performers benefited the greatest from the WSEM by day 5 in the 6MWT, with the rest of the population showing significant improvement over placebo by week 12. The normalized WOMAC Stiffness score was also significantly improved over placebo by day 5 (P?
|
|
|
KEYWORD
|
|
|
cartilage, chondroitin, hyaluronic acid, collagen, glucosamine, dietary supplement, osteoarthritis, water soluble egg shell membrane
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|